Paradoxical changes in lumen size during progression and regression of carotid atherosclerosis
نویسندگان
چکیده
Methods Via CMR (1.5T GE, WI), 35 carotid arteries of 18 asymptomatic, ‘statin naïve’ patients with maximum carotid stenosis >50% (mean 64±21), were imaged at baseline and following 12 months of randomized, blinded statin therapy (simvastatin 40mg or Vytorin (Ezetimibe 10mg/ simvastatin 40mg)). The effects of statins on these lesions were evaluated as changes in carotid outer wall area (OWA), lumen area (LuA), vessel wall area (VWA), lipid area (LpA) and lipid percentage (Lp%). The percentage of stenosis of each slice was determined in reference to a normal or near normal sl.
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